Temporal and spatial congruence of components of motion-onset evoked responses investigated by whole-head magneto-electroencephalography

Motion-onset related components in averaged whole head co-recorded MEG and EEG responses of 24 adults to a low-contrast checkerboard pattern were studied. The aims were to identify these components, to characterize quantitatively their maps and to localize the underlying sources by equivalent-current-dipole (ECD) analyses with a spherical head model.After a weak P1, a large start-elicited negativity arises, comprising the novel N2a (occipital positive and parieto-central negative, peak-latency 141 ms) and the N2 like N2b (bilateral parieto-temporal, 175 ms) component. It is followed by a large positive stop-related component, P2 (156 ms after motion-offset). The corresponding MEG components N2am and N2bm showed bilateral dipole fields with considerable overlap. P1m has a single dipole field around the midline. N2a(m) and N2b(m) can be modelled with two bilateral ECDs with significant different locations. The study shows that accurate mapping and ECD analyses can distinguish two neighbouring areas of the visual cortex, 21+/-4 (SE) mm separated, which activities are reflected in both spatio-temporally closely related N2(m) components. N2a(m) and N2b(m) originate in the extrastriate cortex, possibly close to or in V3/V3A and MT/V5 respectively. Motion-evoked activity in (near) V3/V3A is novel on the basis of EEG data.